Application of the incremental identification method to the formate oxidation using formate dehydrogenase

Abstract:
In this paper we apply the incremental method for the identification of reaction kinetics (Brendel et al., 2006) to the oxidation of formate by dehydrogenase. For the identification task little a priori knowledge is assumed and thus a high number of model candidates have to be considered. In order to identify the best model from a set of candidates the number of candidates is eficiently reduced in a first step using the incremental method. In a second step the best model from the reduced set and its parameters are determined in a statistically sound manner using the classical integral method.

Keywords:
Biocatalysis, Biochemical engineering, Enzyme, Reaction engineering, Model identification, Parameter estimation, Formate dehydrogenase

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