Claas Michalik, T. Schmidt, Michael Zavrel, M. Ansorge-Schumacher, Antje Spieß, Wolfgang Marquardt:
Application of the incremental identification method to the formate oxidation using formate dehydrogenase
Chemical Engineering Science, 2007, 62(3), 5592-5597
In this paper we apply the incremental method for the identification of reaction kinetics (Brendel et al., 2006) to the oxidation of formate by dehydrogenase. For the identification task little a priori knowledge is assumed and thus a high number of model candidates have to be considered. In order to identify the best model from a set of candidates the number of candidates is eficiently reduced in a first step using the incremental method. In a second step the best model from the reduced set and its parameters are determined in a statistically sound manner using the classical integral method.
Biocatalysis, Biochemical engineering, Enzyme, Reaction engineering, Model identification, Parameter estimation, Formate dehydrogenase