Analyse der Fermenation zu Itaconsäure mit Hilfe von metabolischen Netzwerken

Abstract:
Because of a rising energy demand, increasing carbon dioxide emissions and a limited availability of fossil resources renewable raw materials are becoming more and more interesting. The project “Tailor-Made Fuels from Biomass” (TMFB) at RWTH Aachen University takes an approach to research on new synthetic fuels based on biomass. One of the most important platform chemicals from renewable raw materials is itaconic acid. Itaconic acid is usually produced via fermentation by fungi. The aim of this study is to present a metabolic model for the fermentative production of itaconic acid based on literature and experimental data. The first step of the study is to reconstruct a metabolic network for the production of itaconic acid by fungi. Metabolic networks can be constructed and analyzed using Flux Balance Analysis (FBA) in GAMS (General Algebraic Modeling System). The results of the model are compared with the literature and experimental data.

Keywords:
Itakonsäure, Fermentation, Metabolisches Netz