Separating valuable compounds from fermentation supernatants is a challenge in process engineering. Low-temperature separation processes are necessary to meet this challenge. Chromatographic separation processes are among the most selective low-temperature separation processes. They are widely used in the pharmaceutical industry, but also for the purification of bulk chemicals such as sugars and amino acids.
In the chromatography team of AVT.FVT, we aim to extend the process understanding of chromatographic separation processes by combining an experimental and simulative approach. The systematic use of mechanistic, hybrid as well as data-driven simulation models in combination with the application of a sequential methodology for valid model parameter determination build the foundation of our research.
Among other things, we use high-resolution spectroscopic in-line measurement techniques to experimentally validate our modeling and to understand fundamental effects. The chosen combination of experimental and simulative investigations enables us to optimize the selection of chromatographic systems consisting of feed mixture, adsorbent and eluent with respect to a specific application. This also provides an understanding of fundamental effects during a chromatographic separation.
Current research focuses are :
- Data-driven modeling of chromatographic separation processes.
- Use of spectroscopic measurement techniques for in-line process monitoring.
- Evaluation of fundamental effects in ion exchange chromatography of proteins.
Experimental and simulative student research projects as well as bachelor and master theses are regularly available in the research areas mentioned above. Please contact the corresponding person or have a look at the advertised theses at the AVT.FVT.