Computational Systems Biotechnology

  Simulation of fluid dynamics in a chromatography module. Copyright: © AVT

Research Topics

  • Bioprocesses and Bioanalytics
  • Biocatalysis and Biosensors
  • Microscale Bioengineering

The chair of "Computational Systems Biotechnology" (AVT.CSB) headed by Prof. Dr. Wolfgang Wiechert was founded in 2011 as a member of AVT. Simultaneously, Prof. Wiechert is director of the institute IBG-1 (Biotechnology) at Forschungszentrum Jülich. The major research area of IBG-1 is applied systems bio(techno)logy with a special focus on method development for quantitative biology.

Since 2011 Prof Wiechert teaches at RWTH Aachen University. His Chair “Computational Systems Biotechnology“ is part of the AVT. Modeling, simulation and data analysis in systems biology are central aspects of his teaching activities.

The institute IBG-1:Biotechnology at the research Center Jülich is developing biotechnological production processes for platform chemicals, fine chemicals, pharmaceuticals and proteins. The department of „Systems Biotechnology“ headed by Prof. Wiechert is using a systems biology measurement platform (metabolomics, fluxomics, proteomics) in combination with engineering approaches (process engineering, automation, modeling) for a targeted process development at shortened time scales.

In the Jülich institute both whole cell and cell free systems are developed. Central tools for this purpose are quantitative bioanalytical methods and mathematical models used both for the detailed characterization of complex biochemical networks in living cells and for investigating whole bioprocesses. The rational development of enzyme toolboxes for combinatorial biosynthesis paves the way to new chiral molecules in industrial biotechnology and new synthetic metabolic pathways can be established (Synthetic Biology). These activities are complemented by the design of microfluidic devices for single cell analysis accomplished by the development of new fluorescence biosensors.

Publications Computational Systems Biotechnology