Fungi 4 Future – Facilitating Fungal Fed-Batch Fermentations
Do you want to make a change? Do you want to contribute to a sustainable future?
Try Fungal Biotechnology!
According to EUROFUNG, filamentous fungal systems have a huge potential to improve human welfare and to help society to address key challenges of the twenty-first century .
Why do we use filamentous fungi?
Filamentous fungi are often superior to bacterial and yeast based production systems due to their metabolic versatility, robustness and secretory capacity. The benefits of fungal cell factories for white and red biotechnology are demonstrated by the increasing number of established large-scale manufacturing processes for industries including food and feed, pharma, paper and pulp, detergent, textile and bio-fuel. As filamentous fungi already produce the majority of enzymes used worldwide, they are of key importance for a sustainable bio-economy .
What is special about this project?
During your project, you will work with a unique fungal strain that exhibits a well-controlled morphology and is already in use by global players of the pharmaceutical and chemical industry. Your task will be to investigate how the growth, morphology, and enzyme production in small-scale fed-batch systems - microtiter plates und shake flasks - relates to fed-batch fermentations in stirred tank reactors.
How would you achieve your thesis goal?
To achieve the transfer of results from shaken small-scale screening systems to stirred lab-scale production systems (and back) you will employ most or all of the following technologies to analyze fungal growth, productivity and morphology:
- Non-invasive online-Monitoring in microtiter plates and shake flasks
- Innovative fed-batch microtiter plates and shake flasks
- Automation of image analysis or enzyme assays
During your project, you will get…
- … a deeper understanding of biotechnological processes in various scales and the relations between those
- … an introduction into a seminal topic with the flexibility to introduce your own ideas
- … the chance to work on a topic where your results may have a direct impact on a real process
For this project, you should be…
- …motivated to dig deep into a multifaceted topic at the intersection of natural and engineering sciences and discuss your ideas
- …enthusiastic to work in the lab and to get to know, understand and apply novel technologies
- …determined to show a reliable, independent and result-oriented work ethic
The start date of your work on this project is flexible and preferably lies between June and August 2020. If you are interested, do not hesitate to contact me. Whether in English or German, I will gladly provide you with a more detailed project description at a personal meeting.
 Meyer et al. Fungal Biol Biotechnol (2016) : Current challenges of research on filamentous fungi in relation to human welfare and a sustainable bio‑economy: a white paper