Publikationen Computational Systems Biotechnology
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[Fachzeitschriftenartikel]
Mitosch, Karin; Beyß, Martin; Phapale, Prasad; Drotleff, Bernhard; Nöh, Katharina; Alexandrov, Theodore; Patil, Kiran R.; Typas, Athanasios
A pathogen-specific isotope tracing approach reveals metabolic activities and fluxes of intracellular Salmonella
In: PLoS biology, 21 (8), e3002198, 2023
[DOI: 10.1371/journal.pbio.3002198] -
[Fachzeitschriftenartikel]
Heymann, William; Glaser, Juliane; Schlegel, Fabrice; Johnson, Will; Rolandi, Pablo; von Lieres und Wilkau, Eric
Advanced error modeling and Bayesian uncertainty quantification in mechanistic liquid chromatography modeling
In: Journal of chromatography, 1708, 464329, 2023
[DOI: 10.1016/j.chroma.2023.464329] -
[Fachzeitschriftenartikel]
Helleckes, Laura Marie; Müller, Carolin; Griesbach, Tim; Waffenschmidt, Vera; Moch, Matthias; Osthege, Michael; Wiechert, Wolfgang; Oldiges, Marco
Explore or exploit? A model-based screening strategy for PETase secretion by Corynebacterium glutamicum
In: Biotechnology and bioengineering, 120 (1), 139-153, 2022
[DOI: 10.1002/bit.28261] -
[Buchbeitrag, Fachzeitschriftenartikel]
Tenhaef, Niklas; Hermann, Alina; Müller, Moritz Fabian; Görtz, Jonas; Marienhagen, Jan; Oldiges, Marco; Wiechert, Wolfgang; Bott, Michael; Jupke, Andreas; Hartmann, Laura; Herres-Pawlis, Sonja; Noack, Stephan
From Microbial Succinic Acid Production to Polybutylene Bio-Succinate Synthesis
In: Chemie - Ingenieur - Technik : CIT, 95 (4), 587-595, 2023
[DOI: 10.1002/cite.202200163] -
[Buchbeitrag, Beitrag zu einem Tagungsband]
Ruzaeva, Karina; Küsters, Kira; Wiechert, Wolfgang; Berkels, Benjamin; Oldiges, Marco; Noh, Katharina
Automated Characterization of Catalytically Active Inclusion Body Production in Biotechnological Screening Systems
In: 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) / pre-conference workshops & social events: Monday, July 11, 2022, conference dates: Tuesday, July 12-Friday, July 15, 2022 / conference chair: Christopher James (University of Warwick), conference co-chair: James Patton (University of Chicago) ; programm chair: Ron Summers (Collegium Basilea), 3874-3877, 2022
[DOI: 10.1109/EMBC48229.2022.9871325] -
[Fachzeitschriftenartikel]
von den Eichen, Nikolas; Osthege, Michael; Dölle, Michaela; Bromig, Lukas; Wiechert, Wolfgang; Oldiges, Marco; Weuster-Botz, Dirk
Control of parallelized bioreactors II: probabilistic quantification of carboxylic acid reductase activity for bioprocess optimization
In: Bioprocess and biosystems engineering, 45 (12), 1939-1954, 2022
[DOI: 10.1007/s00449-022-02797-7] -
[Doktorarbeit]
Weber, Douglas
Biocatalytic reduction of carboxylic acids : production and application of carboxylate reductases in synthetic enzyme cascades
, 2022
[DOI: 10.18154/RWTH-2022-10375] -
[Fachzeitschriftenartikel]
Sachs, Christian Carsten; Ruzaeva, Karina; Seiffarth, Johannes; Wiechert, Wolfgang; Berkels, Benjamin; Nöh, Katharina
CellSium: versatile cell simulator for microcolony ground truth generation
In: Bioinformatics advances, 2 (1), vbac053, 2022
[DOI: 10.1093/bioadv/vbac053] -
[Fachzeitschriftenartikel]
Schito, Simone; Zuchowski, Rico; Bergen, Daniel; Strohmeier, Daniel; Wollenhaupt, Bastian; Menke, Philipp; Seiffarth, Johannes; Nöh, Katharina; Kohlheyer, Dietrich; Bott, Michael; Wiechert, Wolfgang; Baumgart, Meike; Noack, Stephan
Communities of Niche-optimized Strains (CoNoS) : Design and creation of stable, genome-reduced co-cultures
In: Metabolic engineering, 73, 91-103, 2022
[DOI: 10.1016/j.ymben.2022.06.004] -
[Fachzeitschriftenartikel]
Müller, Carolin C.; Bakkes, Patrick J.; Lenz, Patrick; Waffenschmidt, Vera; Helleckes, Laura Marie; Jaeger, Karl-Erich; Wiechert, Wolfgang; Knapp, Andreas; Freudl, Roland; Oldiges, Marco
Accelerated strain construction and characterization of C. glutamicum protein secretion by laboratory automation
In: Applied microbiology and biotechnology, 106 (12), 4481-4497, 2022
[DOI: 10.1007/s00253-022-12017-7] -
[Fachzeitschriftenartikel]
Küsters, Kira; Saborowski, Ronja; Wagner, Christian; Hamel, Rebecca; Spöring, Jan-Dirk; Wiechert, Wolfgang; Oldiges, Marco
Construction and characterization of BsGDH-CatIB variants and application as robust and highly active redox cofactor regeneration module for biocatalysis
In: Microbial cell factories, 21 (1), 108, 2022
[DOI: 10.1186/s12934-022-01816-2] -
[Fachzeitschriftenartikel]
Nießer, Jochen; Müller, Moritz Fabian; Kappelmann, Jannick; Wiechert, Wolfgang; Noack, Stephan
Hot isopropanol quenching procedure for automated microtiter plate scale 13C-labeling experiments
In: Microbial cell factories, 21 (1), 78, 2022
[DOI: 10.1186/s12934-022-01806-4] -
[Fachzeitschriftenartikel]
Kuppe, Christian W.; Schnepf, Andrea; von Lieres und Wilkau, Eric; Watt, Michelle; Postma, Johannes A.
Rhizosphere models : their concepts and application to plant-soil ecosystems
In: Plant and soil, 474 (1/2), 17-55, 2022
[DOI: 10.1007/s11104-021-05201-7] -
[Fachzeitschriftenartikel]
Helleckes, Laura Marie; Osthege, Michael; Wiechert, Wolfgang; von Lieres und Wilkau, Eric; Oldiges, Marco
Bayesian calibration, process modeling and uncertainty quantification in biotechnology
In: PLoS Computational Biology, 18 (3), e1009223, 2022
[DOI: 10.1371/journal.pcbi.1009223] -
[Fachzeitschriftenartikel]
Labib, Mohamed; Grabowski, Laura; Brüsseler, Christian; Kallscheuer, Nicolai; Wachtendonk, Luisa; Fuchs, Thomas Leonard; Jupke, Andreas; Wiechert, Wolfgang; Marienhagen, Jan; Rother, Dörte; Noack, Stephan
Toward the Sustainable Production of the Active Pharmaceutical Ingredient Metaraminol
In: ACS sustainable chemistry & engineering, 10 (16), 5117-5128, 2022
[DOI: 10.1021/acssuschemeng.1c08275] -
[Buchbeitrag, Fachzeitschriftenartikel]
Reiter, Alexander; Asgari, Jian; Wiechert, Wolfgang; Oldiges, Marco
Metabolic Footprinting of Microbial Systems Based on Comprehensive In Silico Predictions of MS/MS Relevant Data
In: Metabolites : open access journal, 12 (3), 257, 2022
[DOI: 10.3390/metabo12030257] -
[Fachzeitschriftenartikel]
Osthege, Michael; Tenhaef, Niklas; Zyla, Rebecca; Müller, Carolin; Hemmerich, Johannes; Wiechert, Wolfgang; Noack, Stephan; Oldiges, Marco
bletl : A Python package for integrating BioLector microcultivation devices in the Design-Build-Test-Learn cycle
In: Engineering in life sciences, 22 (3/4), 242-259, 2022
[DOI: 10.1002/elsc.202100108] -
[Fachzeitschriftenartikel]
Heymann, William; Glaser, Juliane; Schlegel, Fabrice; Johnson, Will; Rolandi, Pablo; von Lieres und Wilkau, Eric
Advanced score system and automated search strategies for parameter estimation in mechanistic chromatography modeling
In: Journal of chromatography / A, 1661, 462693, 2021
[DOI: 10.1016/j.chroma.2021.462693] -
[Fachzeitschriftenartikel]
Doeker, Moritz Paul Ferdinand; Grabowski, Laura; Rother, Dörte; Jupke, Andreas
In situ reactive extraction with oleic acid for process intensification in amine transaminase catalyzed reactions
In: Green chemistry : GC, 24 (1), 295-304, 2021
[DOI: 10.1039/D1GC03289E] -
[Doktorarbeit]
Labib, Mohamed Mamdouh Ali Abdelmoteleb
Towards hybrid production of fine chemicals and high-value compounds
, 2021
[DOI: 10.18154/RWTH-2022-05460] -
[Buchbeitrag, Fachzeitschriftenartikel]
Kappelmann, Jannick; Klein, Bianca; Papenfuß, Mathias; Lange, Julian; Blombach, Bastian; Takors, Ralf; Wiechert, Wolfgang; Polen, Tino; Noack, Stephan
Comprehensive Analysis of C. glutamicum Anaplerotic Deletion Mutants Under Defined d-Glucose Conditions
In: Frontiers in Bioengineering and Biotechnology, 8, 602936, 2021
[DOI: 10.3389/fbioe.2020.602936] -
[Fachzeitschriftenartikel]
Jansen, Roman; Küsters, Kira; Morschett, Holger; Wiechert, Wolfgang; Oldiges, Marco
A fully automated pipeline for the dynamic at‐line morphology analysis of microscale Aspergillus cultivation
In: Fungal Biology and Biotechnology, 8 (1), [1]-10, 2021
[DOI: 10.1186/s40694-021-00109-4] -
[Doktorarbeit]
Leweke, Samuel
Unified modeling and efficient simulation of chromatographic separation processes
, 2021
[DOI: 10.18154/RWTH-2022-01184] -
[Fachzeitschriftenartikel]
Feierabend, Martina; Renz, Alina; Zelle, Elisabeth; Nöh, Katharina; Wiechert, Wolfgang; Dräger, Andreas
High-Quality Genome-Scale Reconstruction of Corynebacterium glutamicum ATCC 13032
In: Frontiers in microbiology, 12, 750206, 2021
[DOI: 10.3389/fmicb.2021.750206] -
[Fachzeitschriftenartikel]
Kappauf, Katrin; Majstorovic, Nikola; Agarwal, Seema; Rother, Dörte; Claaßen, Christiane
Modulation of Transaminase Activity by Encapsulation in Temperature-Sensitive Poly(N-acryloyl glycinamide) Hydrogels
In: ChemBioChem : a European journal of chemical biology, 22 (24), 3452-3461, 2021
[DOI: 10.1002/cbic.202100427] -
[Buchbeitrag, Fachzeitschriftenartikel]
Siedentop, Regine; Claaßen, Christiane; Rother, Dörte; Lütz, Stephan; Rosenthal, Katrin
Getting the Most Out of Enzyme Cascades : Strategies to Optimize In Vitro Multi-Enzymatic Reactions
In: Catalysts : open access journal, 11 (10), 1183, 2021
[DOI: 10.3390/catal11101183] -
[Fachzeitschriftenartikel]
Müller, Carolin C.; Igwe, Chika L.; Wiechert, Wolfgang; Oldiges, Marco
Scaling production of GFP1-10 detector protein in E. coli for secretion screening by split GFP assay
In: Microbial cell factories, 20 (1), 191, 2021
[DOI: 10.1186/s12934-021-01672-6] -
[Doktorarbeit]
Kaganovitch, Eugen
Development and application of a microfluidic batch cultivation device
, 2021
[DOI: 10.18154/RWTH-2021-09799] -
[Fachzeitschriftenartikel]
Beyß, Martin; Parra-Peña, Victor D.; Ramirez-Malule, Howard; Nöh, Katharina
Robustifying Experimental Tracer Design for $^{13}$C-Metabolic Flux Analysis
In: Frontiers in Bioengineering and Biotechnology, 9, 685323, 2021
[DOI: 10.3389/fbioe.2021.685323] -
[Fachzeitschriftenartikel]
Tenhaef, Niklas; Kappelmann, Jannick; Eich, Arabel; Weiske, Marc; Brieß, Lisette; Brüsseler, Christian; Marienhagen, Jan; Wiechert, Wolfgang; Noack, Stephan
Microaerobic growth-decoupled production of α-ketoglutarate and succinate from xylose in a one-pot process using Corynebacterium glutamicum
In: Biotechnology journal : BTJ, 10, 2100043, 2021
[DOI: 10.1002/biot.202100043] -
[Fachzeitschriftenartikel]
Mack, Kevin; Doeker, Moritz Paul Ferdinand; Grabowski, Laura; Jupke, Andreas; Rother, Dörte
Extractive in situ product removal for the application of naturally produced L-alanine as an amine donor in enzymatic metaraminol production
In: Green chemistry : GC, 23 (13), 4892-4901, 2021
[DOI: 10.1039/D1GC00852H] -
[Fachzeitschriftenartikel]
Morschett, Holger; Tenhaef, Niklas; Hemmerich, Johannes; Herbst, Laura Marie; Spiertz, Markus; Dogan, Deniz; Wiechert, Wolfgang; Noack, Stephan; Oldiges, Marco
Robotic integration enables autonomous operation of laboratory scale stirred tank bioreactors with model-driven process analysis
In: Biotechnology & bioengineering, 118 (7), 2759-2769, 2021
[DOI: 10.1002/bit.27795] -
[Fachzeitschriftenartikel]
van Schie, Morten M. C. H.; Spöring, Jan-Dirk; Bocola, Marco; Domínguez de María, Pablo; Rother, Dörte
Applied biocatalysis beyond just buffers : from aqueous to unconventional media. Options and guidelines
In: Green chemistry : GC, 23 (9), 3191-3206, 2021
[DOI: 10.1039/D1GC00561H] -
[Fachzeitschriftenartikel]
Zelle, E.; Pfelzer, N.; Oldiges, Marco; Koch-Koerfges, A.; Bott, M.; Nöh, K.; Wiechert, W.
An energetic profile of Corynebacterium glutamicum underpinned by measured biomass yield on ATP
In: Metabolic engineering, 65, 66-78, 2021
[DOI: 10.1016/j.ymben.2021.03.006] -
[Fachzeitschriftenartikel]
Gerlach, Tim; Nugroho, David Limanhadi; Rother, Dörte
The Effect of Visible Light on the Catalytic Activity of PLP‐Dependent Enzymes
In: ChemCatChem, 13 (10), 2398-2406, 2021
[DOI: 10.1002/cctc.202100163] -
[Fachzeitschriftenartikel]
Jansen, Roman; Morschett, Holger; Hasenklever, Dennis; Moch, Matthias; Wiechert, Wolfgang; Oldiges, Marco
Microbioreactor‐assisted cultivation workflows for time‐efficient phenotyping of protein producing Aspergillus niger in batch and fed‐batch mode
In: Biotechnology progress, 37 (4), e3144, 2021
[DOI: 10.1002/btpr.3144] -
[Buchbeitrag, Fachzeitschriftenartikel]
Reiter, Alexander; Herbst, Laura Marie; Wiechert, Wolfgang; Oldiges, Marco
Need for speed : evaluation of dilute and shoot-mass spectrometry for accelerated metabolic phenotyping in bioprocess development
In: Analytical and bioanalytical chemistry, 413 (12), 3253-3268, 2021
[DOI: 10.1007/s00216-021-03261-3] -
[Fachzeitschriftenartikel]
Weber, Douglas; Patsch, David; Neumann, Annika; Winkler, Margit; Rother, Dörte
Production of the Carboxylate Reductase from Nocardia otitidiscaviarum in a Soluble, Active Form for in vitro Applications
In: ChemBioChem : a European journal of chemical biology, 22 (10), 1823-1832, 2021
[DOI: 10.1002/cbic.202000846] -
[Fachzeitschriftenartikel]
Küsters, Kira; Pohl, Martina; Krauss, Ulrich; Ölçücü, Gizem; Albert, Sandor; Jaeger, Karl-Erich; Wiechert, Wolfgang; Oldiges, Marco
Construction and comprehensive characterization of an EcLDCc-CatIB set—varying linkers and aggregation inducing tags
In: Microbial cell factories, 20 (1), 49, 2021
[DOI: 10.1186/s12934-021-01539-w] -
[Fachzeitschriftenartikel]
Rother, Dörte; Malzacher, Stephan
Computer-aided enzymatic retrosynthesis
In: Nature catalysis, 4 (2), 92-93, 2021
[DOI: 10.1038/s41929-021-00582-5] -
[Buchbeitrag, Fachzeitschriftenartikel]
Hemmerich, Johannes; Tenhaef, Niklas; Wiechert, Wolfgang; Noack, Stephan
pyFOOMB: Python framework for object oriented modeling of bioprocesses
In: Engineering in life sciences, 21 (3/4), 242-257, 2021
[DOI: 10.1002/elsc.202000088] -
[Doktorarbeit]
Schätzle, Lisa-Katrin
Translational modeling of drug efficacy in cancer
, 2020
[DOI: 10.18154/RWTH-2020-11329] -
[Fachzeitschriftenartikel]
Hemmerich, Johannes; Labib, Mohamed; Steffens, Carmen; Reich, Sebastian J.; Weiske, Marc; Baumgart, Meike; Rückert, Christian; Ruwe, Matthias; Siebert, Daniel; Wendisch, Volker F.; Kalinowski, Jörn; Wiechert, Wolfgang; Oldiges, Marco
Screening of a genome-reduced Corynebacterium glutamicum strain library for improved heterologous cutinase secretion
In: Microbial biotechnology, 10, 1751-7915.13660, 2020
[DOI: 10.1111/1751-7915.13660] -
[Doktorarbeit]
Bucher-Krämer, Christina Erna Maria
Multiplexed intracellular single-cell sensing strategies of microorganisms integrated for cultivation in microfluidic devices
, 2020
[DOI: 10.18154/RWTH-2020-03855] -
[Fachzeitschriftenartikel]
Morschett, Holger; Jansen, Roman; Neuendorf, Christian; Moch, Matthias; Wiechert, Wolfgang; Oldiges, Marco
Parallelized microscale fed-batch cultivation in online-monitored microtiter plates : implications of media composition and feed strategies for process design and performance
In: Journal of industrial microbiology & biotechnology, 47 (1), 35-47, 2019
[DOI: 10.1007/s10295-019-02243-w] -
[Fachzeitschriftenartikel]
Pooth, Viola; Gaalen, Kathrin; Trenkamp, Sandra; Wiechert, Wolfgang; Oldiges, Marco
Comprehensive analysis of metabolic sensitivity of 1,4-butanediol producing Escherichia coli toward substrate and oxygen availability
In: Biotechnology progress, 36 (1), e2917, 2019
[DOI: 10.1002/btpr.2917] -
[Beitrag zu einem Tagungsband]
Rao, Jayghosh Subodh; Puettmann, Andreas; Behr, Marek; von Lieres und Wilkau, Eric
High Definition Simulation of Packed Bed Liquid Chromatography
In: [15th International PhD Seminar on Chromatographic Separation Science, SoCSS 2019, 2019-02-24 - 2019-02-26, Quedlinburg, Germany], 2019 -
[Fachzeitschriftenartikel]
Hemmerich, Johannes; Moch, Matthias; Jurischka, Sarah; Wiechert, Wolfgang; Freudl, Roland; Oldiges, Marco
Combinatorial impact of Sec signal peptides from Bacillus subtilis and bioprocess conditions on heterologous cutinase secretion by Corynebacterium glutamicum
In: Biotechnology & bioengineering, 116 (3), 644-655, 2018
[DOI: 10.1002/bit.26873] -
[Fachzeitschriftenartikel]
Burmeister, Alina; Hilgers, Fabienne; Langner, Annika; Westerwalbesloh, Christoph; Kerkhoff, Yannic; Tenhaef, Niklas; Drepper, Thomas; Kohlheyer, Dietrich; von Lieres und Wilkau, Eric; Noack, Stephan; Grünberger, Alexander
A microfluidic co-cultivation platform to investigate microbial interactions at defined microenvironments
In: Lab on a chip, 19 (1), 98-110, 2018
[DOI: 10.1039/C8LC00977E] -
[Buchbeitrag, Fachzeitschriftenartikel]
Hemmerich, Johannes; Tenhaef, Niklas; Steffens, Carmen; Kappelmann, Jannick; Weiske, Marc; Reich, Sebastian J.; Wiechert, Wolfgang; Oldiges, Marco; Noack, Stephan
Less Sacrifice, More Insight: Repeated Low-Volume Sampling of Microbioreactor Cultivations Enables Accelerated Deep Phenotyping of Microbial Strain Libraries
In: Biotechnology journal, 14 (9), 1800428, 2018
[DOI: 10.1002/biot.201800428]
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