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Publications

Titel	Author(s)
CellSium: versatile cell simulator for microcolony ground truth generation Erschienen in: Bioinformatics advances (2022)	Sachs, Christian Carsten Ruzaeva, Karina Seiffarth, Johannes Wiechert, Wolfgang Berkels, Benjamin Nöh, Katharina (Corresponding author)
Communities of Niche-optimized Strains (CoNoS) : Design and creation of stable, genome-reduced co-cultures Erschienen in: Metabolic engineering (2022)	Schito, Simone Zuchowski, Rico Bergen, Daniel Strohmeier, Daniel Wollenhaupt, Bastian Menke, Philipp Seiffarth, Johannes Nöh, Katharina Kohlheyer, Dietrich Bott, Michael Wiechert, Wolfgang Baumgart, Meike Noack, Stephan (Corresponding author)
Accelerated strain construction and characterization of C. glutamicum protein secretion by laboratory automation Erschienen in: Applied microbiology and biotechnology (2022)	Müller, Carolin Bakkes, Patrick J. Lenz, Patrick Waffenschmidt, Vera Helleckes, Laura M. Jaeger, Karl-Erich Wiechert, Wolfgang Knapp, Andreas Freudl, Roland Oldiges, Marco (Corresponding author)
Construction and characterization of BsGDH-CatIB variants and application as robust and highly active redox cofactor regeneration module for biocatalysis Erschienen in: Microbial cell factories (2022)	Küsters, Kira Saborowski, Ronja Wagner, Christian Hamel, Rebecca Spöring, Jan-Dirk Wiechert, Wolfgang Oldiges, Marco (Corresponding author)
Hot isopropanol quenching procedure for automated microtiter plate scale 13C-labeling experiments Erschienen in: Microbial cell factories (2022)	Nießer, Jochen Müller, Moritz Fabian Kappelmann, Jannick Wiechert, Wolfgang Noack, Stephan (Corresponding author)
Bayesian calibration, process modeling and uncertainty quantification in biotechnology Erschienen in: PLoS Computational Biology (2022)	Helleckes, Laura Marie Osthege, Michael Wiechert, Wolfgang von Lieres und Wilkau, Eric Oldiges, Marco (Corresponding author)
Toward the Sustainable Production of the Active Pharmaceutical Ingredient Metaraminol Erschienen in: ACS sustainable chemistry & engineering (2022)	Labib, Mohamed Grabowski, Laura Brüsseler, Christian Kallscheuer, Nicolai Wachtendonk, Luisa Fuchs, Thomas Leonard Jupke, Andreas Wiechert, Wolfgang Marienhagen, Jan Rother, Dörte Noack, Stephan (Corresponding author)
Metabolic Footprinting of Microbial Systems Based on Comprehensive In Silico Predictions of MS/MS Relevant Data Erschienen in: Metabolites : open access journal (2022)	Reiter, Alexander Asgari, Jian Wiechert, Wolfgang Oldiges, Marco (Corresponding author)
bletl : A Python package for integrating BioLector microcultivation devices in the Design-Build-Test-Learn cycle Erschienen in: Engineering in life sciences (2022)	Osthege, Michael Tenhaef, Niklas Zyla, Rebecca Müller, Carolin Hemmerich, Johannes Wiechert, Wolfgang Noack, Stephan Oldiges, Marco (Corresponding author)
Comprehensive Analysis of C. glutamicum Anaplerotic Deletion Mutants Under Defined d-Glucose Conditions Erschienen in: Frontiers in Bioengineering and Biotechnology (2021)	Kappelmann, Jannick Klein, Bianca Papenfuß, Mathias Lange, Julian Blombach, Bastian Takors, Ralf Wiechert, Wolfgang Polen, Tino Noack, Stephan (Corresponding author)
A fully automated pipeline for the dynamic at‐line morphology analysis of microscale Aspergillus cultivation Erschienen in: Fungal Biology and Biotechnology (2021)	Jansen, Roman Küsters, Kira Morschett, Holger Wiechert, Wolfgang Oldiges, Marco (Corresponding author)
High-Quality Genome-Scale Reconstruction of Corynebacterium glutamicum ATCC 13032 Erschienen in: Frontiers in microbiology (2021)	Feierabend, Martina Renz, Alina Zelle, Elisabeth Nöh, Katharina Wiechert, Wolfgang Dräger, Andreas (Corresponding author)
Scaling production of GFP1-10 detector protein in E. coli for secretion screening by split GFP assay Erschienen in: Microbial cell factories (2021)	Müller, Carolin C. Igwe, Chika L. Wiechert, Wolfgang Oldiges, Marco (Corresponding author)
Microaerobic growth-decoupled production of α-ketoglutarate and succinate from xylose in a one-pot process using Corynebacterium glutamicum Erschienen in: Biotechnology journal : BTJ (2021)	Tenhaef, Niklas Kappelmann, Jannick Eich, Arabel Weiske, Marc Brieß, Lisette Brüsseler, Christian Marienhagen, Jan Wiechert, Wolfgang Noack, Stephan (Corresponding author)
Robotic integration enables autonomous operation of laboratory scale stirred tank bioreactors with model-driven process analysis Erschienen in: Biotechnology & bioengineering (2021)	Morschett, Holger Tenhaef, Niklas Hemmerich, Johannes Herbst, Laura Marie Spiertz, Markus Dogan, Deniz Wiechert, Wolfgang Noack, Stephan Oldiges, Marco (Corresponding author)
An energetic profile of Corynebacterium glutamicum underpinned by measured biomass yield on ATP Erschienen in: Metabolic engineering (2021)	Zelle, E. Pfelzer, N. Oldiges, Marco Koch-Koerfges, A. Bott, M. Nöh, K. Wiechert, W. (Corresponding author)
Microbioreactor‐assisted cultivation workflows for time‐efficient phenotyping of protein producing Aspergillus niger in batch and fed‐batch mode Erschienen in: Biotechnology progress (2021)	Jansen, Roman Morschett, Holger Hasenklever, Dennis Moch, Matthias Wiechert, Wolfgang Oldiges, Marco (Corresponding author)
Need for speed : evaluation of dilute and shoot-mass spectrometry for accelerated metabolic phenotyping in bioprocess development Erschienen in: Analytical and bioanalytical chemistry (2021)	Reiter, Alexander Herbst, Laura Marie Wiechert, Wolfgang Oldiges, Marco (Corresponding author)
Construction and comprehensive characterization of an EcLDCc-CatIB set—varying linkers and aggregation inducing tags Erschienen in: Microbial cell factories (2021)	Küsters, Kira Pohl, Martina Krauss, Ulrich Ölçücü, Gizem Albert, Sandor Jaeger, Karl-Erich Wiechert, Wolfgang Oldiges, Marco (Corresponding author)
pyFOOMB: Python framework for object oriented modeling of bioprocesses Erschienen in: Engineering in life sciences (2021)	Hemmerich, Johannes Tenhaef, Niklas Wiechert, Wolfgang Noack, Stephan (Corresponding author)
Screening of a genome-reduced Corynebacterium glutamicum strain library for improved heterologous cutinase secretion Erschienen in: Microbial biotechnology (2020)	Hemmerich, Johannes Labib, Mohamed Steffens, Carmen Reich, Sebastian J. Weiske, Marc Baumgart, Meike Rückert, Christian Ruwe, Matthias Siebert, Daniel Wendisch, Volker F. Kalinowski, Jörn Wiechert, Wolfgang Oldiges, Marco (Corresponding author)
Analysis of the local well‐posedness of optimization‐constrained differential equations by local optimality conditions Erschienen in: AIChE journal (2020)	Zhao, Xiao Ploch, Tobias Michael Noack, Stephan Wiechert, Wolfgang Mitsos, Alexander (Corresponding author) von Lieres, Eric (Corresponding author)
Simulation of differential-algebraic equation systems with optimization criteria embedded in Modelica Erschienen in: Computers & chemical engineering (2020)	Ploch, Tobias Michael von Lieres und Wilkau, Eric Wiechert, Wolfgang Mitsos, Alexander Hannemann-Tamás, Ralf (Corresponding author)
Parallelized microscale fed-batch cultivation in online-monitored microtiter plates : implications of media composition and feed strategies for process design and performance Erschienen in: Journal of industrial microbiology & biotechnology (2019)	Morschett, Holger (Corresponding author) Jansen, Roman Neuendorf, Christian Moch, Matthias Wiechert, Wolfgang Oldiges, Marco (Corresponding author)
Comprehensive analysis of metabolic sensitivity of 1,4-butanediol producing Escherichia coli toward substrate and oxygen availability Erschienen in: Biotechnology progress (2019)	Pooth, Viola Gaalen, Kathrin Trenkamp, Sandra Wiechert, Wolfgang Oldiges, Marco (Corresponding author)
Combinatorial impact of Sec signal peptides from Bacillus subtilis and bioprocess conditions on heterologous cutinase secretion by Corynebacterium glutamicum Erschienen in: Biotechnology & bioengineering (2018)	Hemmerich, Johannes Moch, Matthias Jurischka, Sarah Wiechert, Wolfgang Freudl, Roland Oldiges, Marco (Corresponding author)
Less Sacrifice, More Insight: Repeated Low-Volume Sampling of Microbioreactor Cultivations Enables Accelerated Deep Phenotyping of Microbial Strain Libraries Erschienen in: Biotechnology journal (2018)	Hemmerich, Johannes Tenhaef, Niklas Steffens, Carmen Kappelmann, Jannick Weiske, Marc Reich, Sebastian J. Wiechert, Wolfgang Oldiges, Marco Noack, Stephan (Corresponding author)
Multiscale dynamic modeling and simulation of a biorefinery Erschienen in: Biotechnology & bioengineering (2019)	Ploch, Tobias Michael Zhao, Xiao Hüser, Jonathan von Lieres und Wilkau, Eric Hannemann-Tamás, Ralf Naumann, Uwe Wiechert, Wolfgang Mitsos, Alexander (Corresponding author) Noack, Stephan (Corresponding author)
Corrigendum: The Design of FluxML: A Universal Modeling Language for 13C Metabolic Flux Analysis Erschienen in: Frontiers in microbiology (2019)	Beyß, Martin Azzouzi, Salah Weitzel, Michael Wiechert, Wolfgang Nöh, Katharina (Corresponding author)
The Design of FluxML: A Universal Modeling Language for 13C Metabolic Flux Analysis Erschienen in: Frontiers in microbiology (2019)	Beyß, Martin Azzouzi, Salah Weitzel, Michael Wiechert, Wolfgang Nöh, Katharina (Corresponding author)
Quantitative measurements in single-cell analysis: towards scalability in microbial bioprocess development Erschienen in: Current opinion in biotechnology (2018)	Demling, Philipp Westerwalbesloh, Christoph Noack, Stephan Wiechert, Wolfgang Kohlheyer, Dietrich
Germination and Growth Analysis of Streptomyces lividans at the Single-Cell Level Under Varying Medium Compositions Erschienen in: Frontiers in microbiology (2018)	Koepff, Joachim Sachs, Christian Carsten Wiechert, Wolfgang Kohlheyer, Dietrich Nöh, Katharina Oldiges, Marco Grünberger, Alexander (Corresponding author)
Application of Mass Spectrometry-based Metabolomics and Fluxomics for Biotechnological Strain Improvement (2018)	Weber, Dieter (Corresponding author) Beyß, Martin Mampel, Jörg Wiechert, Wolfgang Blank, Lars M. Nöh, Katharina Ebert, Birgitta Elisabeth
Framework for Multi-Scale Modeling and Dynamic Simulation of a Biorefinery (2018)	Ploch, Tobias Michael Zhao, Xiao Tenhaef, Niklas Hüser, Jonathan Lieres, von Eric Hannemann-Tamás, Ralf Naumann, Uwe Wiechert, Wolfgang Mitsos, Alexander (Corresponding author) Noack, Stephan
HiQFlux: Quantifying metabolic network operation in compartmentalized organisms - yeast as a eukaryotic model (2017)	Beyß, Martin Weber, Dieter Blank, Lars M. Wiechert, Wolfgang Ebert, Birgitta Elisabeth (Corresponding author) Nöh, Katharina
Homogenizing bacterial cell factories : Analysis and engineering of phenotypic heterogeneity Erschienen in: Metabolic engineering (2017)	Binder, Dennis (Corresponding author) Drepper, Thomas Jaeger, Karl-Erich Delvigne, Frank Wiechert, Wolfgang Kohlheyer, Dietrich Grünberger, Alexander (Corresponding author)
Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology Erschienen in: Journal of visualized experiments (2017)	Hemmerich, Johannes Freier, Lars Wiechert, Wolfgang von Lieres und Wilkau, Eric (Corresponding author) Oldiges, Marco (Corresponding author)
40 Years of Biotechnology Research at Forschungszentrum Jülich Erschienen in: Journal of biotechnology (2017)	Bott, Michael (Editor) Jaeger, Karl-Erich (Editor) Pietruszka, Jörg (Editor) Wiechert, Wolfgang (Editor)
HiQFlux: Quantifying metabolic network operation in compartmentalized organisms - yeast as a eukaryotic model (2016)	Ebert, Birgitta Elisabeth Nöh, Katharina Wiechert, Wolfgang Blank, Lars M.
A Toolbox of Genetically Encoded FRET-Based Biosensors for Rapid l-Lysine Analysis Erschienen in: Sensors (2016)	Steffen, Victoria Otten, Julia Engelmann, Susann Radek, Andreas Limberg, Michael Koenig, Bernd Noack, Stephan Wiechert, Wolfgang Pohl, Martina (Corresponding author)
Photocaged Arabinose: A Novel Optogenetic Switch for Rapid and Gradual Control of Microbial Gene Expression Erschienen in: ChemBioChem (2016)	Binder, Dennis (Corresponding author) Bier, Claus Grünberger, Alexander Drobietz, Dagmar Hage-Hülsmann, Jennifer Wandrey, Georg Benjamin Büchs, Jochen Kohlheyer, Dietrich Loeschcke, Anita Wiechert, Wolfgang Jaeger, Karl-Erich Pietruszka, Jörg Drepper, Thomas
Rapid assessment of oxygen transfer impact for Corynebacterium glutamicum Erschienen in: Bioprocess and biosystems engineering (2014)	Käß, Friedrich Prasad, Arjun Tillack, Jana Moch, Matthias Giese, Heiner Büchs, Jochen Wiechert, Wolfgang Oldiges, Marco (Corresponding author)
First- and Second-Order Parameter Sensitivities of a Metabolically and Isotopically Non-Stationary Biochemical Network Model Erschienen in: Proceedings - 9th International Modelica Conference : September 3 - 5, 2012, Munich, Germany / , Martin Otter ; Dirk Zimmer (2012)	Hannemann-Tamás, Ralf Tillack, Jana Schmitz, Moritz Förster, Michael Wyes, Jutta Nöh, Katharina von Lieres und Wilkau, Eric Naumann, Uwe Wiechert, Wolfgang Marquardt, Wolfgang