Person
Dr. rer. nat., UniversitätsprofessorWolfgang Wiechert
Professorship
Computational Systems Biotechnology
Address
FZ Jülich GmbH, IBG-1
52425 Jülich
Resume
More informationen about Wolfgang Wiechert you can find here
Publications
Publications
| Titel | Author(s) |
|---|---|
| From Microbial Succinic Acid Production to Polybutylene Bio‐Succinate Synthesis Erschienen in: Chemie - Ingenieur - Technik (2023) | Tenhaef, Niklas Hermann, Alina Müller, Moritz Fabian Görtz, Jonas Marienhagen, Jan Oldiges, Marco Wiechert, Wolfgang Bott, Michael Jupke, Andreas Hartmann, Laura Herres-Pawlis, Sonja Noack, Stephan |
| Control of parallelized bioreactors II: probabilistic quantification of carboxylic acid reductase activity for bioprocess optimization Erschienen in: Bioprocess and biosystems engineering (2022) | von den Eichen, Nikolas (Corresponding author) Osthege, Michael Dölle, Michaela Bromig, Lukas Wiechert, Wolfgang Oldiges, Marco Weuster-Botz, Dirk |
| CellSium: versatile cell simulator for microcolony ground truth generation Erschienen in: Bioinformatics advances (2022) | Sachs, Christian Carsten Ruzaeva, Karina Seiffarth, Johannes Wiechert, Wolfgang Berkels, Benjamin Nöh, Katharina (Corresponding author) |
| Communities of Niche-optimized Strains (CoNoS) : Design and creation of stable, genome-reduced co-cultures Erschienen in: Metabolic engineering (2022) | Schito, Simone Zuchowski, Rico Bergen, Daniel Strohmeier, Daniel Wollenhaupt, Bastian Menke, Philipp Seiffarth, Johannes Nöh, Katharina Kohlheyer, Dietrich Bott, Michael Wiechert, Wolfgang Baumgart, Meike Noack, Stephan (Corresponding author) |
| Accelerated strain construction and characterization of C. glutamicum protein secretion by laboratory automation Erschienen in: Applied microbiology and biotechnology (2022) | Müller, Carolin Bakkes, Patrick J. Lenz, Patrick Waffenschmidt, Vera Helleckes, Laura M. Jaeger, Karl-Erich Wiechert, Wolfgang Knapp, Andreas Freudl, Roland Oldiges, Marco (Corresponding author) |
| Construction and characterization of BsGDH-CatIB variants and application as robust and highly active redox cofactor regeneration module for biocatalysis Erschienen in: Microbial cell factories (2022) | Küsters, Kira Saborowski, Ronja Wagner, Christian Hamel, Rebecca Spöring, Jan-Dirk Wiechert, Wolfgang Oldiges, Marco (Corresponding author) |
| Hot isopropanol quenching procedure for automated microtiter plate scale 13C-labeling experiments Erschienen in: Microbial cell factories (2022) | Nießer, Jochen Müller, Moritz Fabian Kappelmann, Jannick Wiechert, Wolfgang Noack, Stephan (Corresponding author) |
| Bayesian calibration, process modeling and uncertainty quantification in biotechnology Erschienen in: PLoS Computational Biology (2022) | Helleckes, Laura Marie Osthege, Michael Wiechert, Wolfgang von Lieres und Wilkau, Eric Oldiges, Marco (Corresponding author) |
| Toward the Sustainable Production of the Active Pharmaceutical Ingredient Metaraminol Erschienen in: ACS sustainable chemistry & engineering (2022) | Labib, Mohamed Grabowski, Laura Brüsseler, Christian Kallscheuer, Nicolai Wachtendonk, Luisa Fuchs, Thomas Leonard Jupke, Andreas Wiechert, Wolfgang Marienhagen, Jan Rother, Dörte Noack, Stephan (Corresponding author) |
| Metabolic Footprinting of Microbial Systems Based on Comprehensive In Silico Predictions of MS/MS Relevant Data Erschienen in: Metabolites : open access journal (2022) | Reiter, Alexander Asgari, Jian Wiechert, Wolfgang Oldiges, Marco (Corresponding author) |
| bletl : A Python package for integrating BioLector microcultivation devices in the Design-Build-Test-Learn cycle Erschienen in: Engineering in life sciences (2022) | Osthege, Michael Tenhaef, Niklas Zyla, Rebecca Müller, Carolin Hemmerich, Johannes Wiechert, Wolfgang Noack, Stephan Oldiges, Marco (Corresponding author) |
| Comprehensive Analysis of C. glutamicum Anaplerotic Deletion Mutants Under Defined d-Glucose Conditions Erschienen in: Frontiers in Bioengineering and Biotechnology (2021) | Kappelmann, Jannick Klein, Bianca Papenfuß, Mathias Lange, Julian Blombach, Bastian Takors, Ralf Wiechert, Wolfgang Polen, Tino Noack, Stephan (Corresponding author) |
| A fully automated pipeline for the dynamic at‐line morphology analysis of microscale Aspergillus cultivation Erschienen in: Fungal Biology and Biotechnology (2021) | Jansen, Roman Küsters, Kira Morschett, Holger Wiechert, Wolfgang Oldiges, Marco (Corresponding author) |
| High-Quality Genome-Scale Reconstruction of Corynebacterium glutamicum ATCC 13032 Erschienen in: Frontiers in microbiology (2021) | Feierabend, Martina Renz, Alina Zelle, Elisabeth Nöh, Katharina Wiechert, Wolfgang Dräger, Andreas (Corresponding author) |
| Scaling production of GFP1-10 detector protein in E. coli for secretion screening by split GFP assay Erschienen in: Microbial cell factories (2021) | Müller, Carolin C. Igwe, Chika L. Wiechert, Wolfgang Oldiges, Marco (Corresponding author) |
| Microaerobic growth-decoupled production of α-ketoglutarate and succinate from xylose in a one-pot process using Corynebacterium glutamicum Erschienen in: Biotechnology journal : BTJ (2021) | Tenhaef, Niklas Kappelmann, Jannick Eich, Arabel Weiske, Marc Brieß, Lisette Brüsseler, Christian Marienhagen, Jan Wiechert, Wolfgang Noack, Stephan (Corresponding author) |
| Robotic integration enables autonomous operation of laboratory scale stirred tank bioreactors with model-driven process analysis Erschienen in: Biotechnology & bioengineering (2021) | Morschett, Holger Tenhaef, Niklas Hemmerich, Johannes Herbst, Laura Marie Spiertz, Markus Dogan, Deniz Wiechert, Wolfgang Noack, Stephan Oldiges, Marco (Corresponding author) |
| An energetic profile of Corynebacterium glutamicum underpinned by measured biomass yield on ATP Erschienen in: Metabolic engineering (2021) | Zelle, E. Pfelzer, N. Oldiges, Marco Koch-Koerfges, A. Bott, M. Nöh, K. Wiechert, W. (Corresponding author) |
| Microbioreactor‐assisted cultivation workflows for time‐efficient phenotyping of protein producing Aspergillus niger in batch and fed‐batch mode Erschienen in: Biotechnology progress (2021) | Jansen, Roman Morschett, Holger Hasenklever, Dennis Moch, Matthias Wiechert, Wolfgang Oldiges, Marco (Corresponding author) |
| Need for speed : evaluation of dilute and shoot-mass spectrometry for accelerated metabolic phenotyping in bioprocess development Erschienen in: Analytical and bioanalytical chemistry (2021) | Reiter, Alexander Herbst, Laura Marie Wiechert, Wolfgang Oldiges, Marco (Corresponding author) |
| Construction and comprehensive characterization of an EcLDCc-CatIB set—varying linkers and aggregation inducing tags Erschienen in: Microbial cell factories (2021) | Küsters, Kira Pohl, Martina Krauss, Ulrich Ölçücü, Gizem Albert, Sandor Jaeger, Karl-Erich Wiechert, Wolfgang Oldiges, Marco (Corresponding author) |
| pyFOOMB: Python framework for object oriented modeling of bioprocesses Erschienen in: Engineering in life sciences (2021) | Hemmerich, Johannes Tenhaef, Niklas Wiechert, Wolfgang Noack, Stephan (Corresponding author) |
| Screening of a genome-reduced Corynebacterium glutamicum strain library for improved heterologous cutinase secretion Erschienen in: Microbial biotechnology (2020) | Hemmerich, Johannes Labib, Mohamed Steffens, Carmen Reich, Sebastian J. Weiske, Marc Baumgart, Meike Rückert, Christian Ruwe, Matthias Siebert, Daniel Wendisch, Volker F. Kalinowski, Jörn Wiechert, Wolfgang Oldiges, Marco (Corresponding author) |
| Analysis of the local well‐posedness of optimization‐constrained differential equations by local optimality conditions Erschienen in: AIChE journal (2020) | Zhao, Xiao Ploch, Tobias Michael Noack, Stephan Wiechert, Wolfgang Mitsos, Alexander (Corresponding author) von Lieres und Wilkau, Eric (Corresponding author) |
| Simulation of differential-algebraic equation systems with optimization criteria embedded in Modelica Erschienen in: Computers & chemical engineering (2020) | Ploch, Tobias Michael von Lieres und Wilkau, Eric Wiechert, Wolfgang Mitsos, Alexander Hannemann-Tamás, Ralf (Corresponding author) |
| Parallelized microscale fed-batch cultivation in online-monitored microtiter plates : implications of media composition and feed strategies for process design and performance Erschienen in: Journal of industrial microbiology & biotechnology (2019) | Morschett, Holger (Corresponding author) Jansen, Roman Neuendorf, Christian Moch, Matthias Wiechert, Wolfgang Oldiges, Marco (Corresponding author) |
| Comprehensive analysis of metabolic sensitivity of 1,4-butanediol producing Escherichia coli toward substrate and oxygen availability Erschienen in: Biotechnology progress (2019) | Pooth, Viola Gaalen, Kathrin Trenkamp, Sandra Wiechert, Wolfgang Oldiges, Marco (Corresponding author) |
| Combinatorial impact of Sec signal peptides from Bacillus subtilis and bioprocess conditions on heterologous cutinase secretion by Corynebacterium glutamicum Erschienen in: Biotechnology & bioengineering (2018) | Hemmerich, Johannes Moch, Matthias Jurischka, Sarah Wiechert, Wolfgang Freudl, Roland Oldiges, Marco (Corresponding author) |
| Less Sacrifice, More Insight: Repeated Low-Volume Sampling of Microbioreactor Cultivations Enables Accelerated Deep Phenotyping of Microbial Strain Libraries Erschienen in: Biotechnology journal (2018) | Hemmerich, Johannes Tenhaef, Niklas Steffens, Carmen Kappelmann, Jannick Weiske, Marc Reich, Sebastian J. Wiechert, Wolfgang Oldiges, Marco Noack, Stephan (Corresponding author) |
| Multiscale dynamic modeling and simulation of a biorefinery Erschienen in: Biotechnology & bioengineering (2019) | Ploch, Tobias Michael Zhao, Xiao Hüser, Jonathan von Lieres und Wilkau, Eric Hannemann-Tamás, Ralf Naumann, Uwe Wiechert, Wolfgang Mitsos, Alexander (Corresponding author) Noack, Stephan (Corresponding author) |
| Corrigendum: The Design of FluxML: A Universal Modeling Language for 13C Metabolic Flux Analysis Erschienen in: Frontiers in microbiology (2019) | Beyß, Martin Azzouzi, Salah Weitzel, Michael Wiechert, Wolfgang Nöh, Katharina (Corresponding author) |
| The Design of FluxML: A Universal Modeling Language for 13C Metabolic Flux Analysis Erschienen in: Frontiers in microbiology (2019) | Beyß, Martin Azzouzi, Salah Weitzel, Michael Wiechert, Wolfgang Nöh, Katharina (Corresponding author) |
| Quantitative measurements in single-cell analysis: towards scalability in microbial bioprocess development Erschienen in: Current opinion in biotechnology (2018) | Demling, Philipp Westerwalbesloh, Christoph Noack, Stephan Wiechert, Wolfgang Kohlheyer, Dietrich |
| Germination and Growth Analysis of Streptomyces lividans at the Single-Cell Level Under Varying Medium Compositions Erschienen in: Frontiers in microbiology (2018) | Koepff, Joachim Sachs, Christian Carsten Wiechert, Wolfgang Kohlheyer, Dietrich Nöh, Katharina Oldiges, Marco Grünberger, Alexander (Corresponding author) |
| Application of Mass Spectrometry-based Metabolomics and Fluxomics for Biotechnological Strain Improvement (2018) | Weber, Dieter (Corresponding author) Beyß, Martin Mampel, Jörg Wiechert, Wolfgang Blank, Lars M. Nöh, Katharina Ebert, Birgitta Elisabeth |
| Framework for Multi-Scale Modeling and Dynamic Simulation of a Biorefinery (2018) | Ploch, Tobias Michael Zhao, Xiao Tenhaef, Niklas Hüser, Jonathan Lieres, von Eric Hannemann-Tamás, Ralf Naumann, Uwe Wiechert, Wolfgang Mitsos, Alexander (Corresponding author) Noack, Stephan |
| HiQFlux: Quantifying metabolic network operation in compartmentalized organisms - yeast as a eukaryotic model (2017) | Beyß, Martin Weber, Dieter Blank, Lars M. Wiechert, Wolfgang Ebert, Birgitta Elisabeth (Corresponding author) Nöh, Katharina |
| Homogenizing bacterial cell factories : Analysis and engineering of phenotypic heterogeneity Erschienen in: Metabolic engineering (2017) | Binder, Dennis (Corresponding author) Drepper, Thomas Jaeger, Karl-Erich Delvigne, Frank Wiechert, Wolfgang Kohlheyer, Dietrich Grünberger, Alexander (Corresponding author) |
| Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology Erschienen in: Journal of visualized experiments (2017) | Hemmerich, Johannes Freier, Lars Wiechert, Wolfgang von Lieres und Wilkau, Eric (Corresponding author) Oldiges, Marco (Corresponding author) |
| 40 Years of Biotechnology Research at Forschungszentrum Jülich Erschienen in: Journal of biotechnology (2017) | Bott, Michael (Editor) Jaeger, Karl-Erich (Editor) Pietruszka, Jörg (Editor) Wiechert, Wolfgang (Editor) |
| HiQFlux: Quantifying metabolic network operation in compartmentalized organisms - yeast as a eukaryotic model (2016) | Ebert, Birgitta Elisabeth Nöh, Katharina Wiechert, Wolfgang Blank, Lars M. |
| A Toolbox of Genetically Encoded FRET-Based Biosensors for Rapid l-Lysine Analysis Erschienen in: Sensors (2016) | Steffen, Victoria Otten, Julia Engelmann, Susann Radek, Andreas Limberg, Michael Koenig, Bernd Noack, Stephan Wiechert, Wolfgang Pohl, Martina (Corresponding author) |
| Photocaged Arabinose: A Novel Optogenetic Switch for Rapid and Gradual Control of Microbial Gene Expression Erschienen in: ChemBioChem (2016) | Binder, Dennis (Corresponding author) Bier, Claus Grünberger, Alexander Drobietz, Dagmar Hage-Hülsmann, Jennifer Wandrey, Georg Benjamin Büchs, Jochen Kohlheyer, Dietrich Loeschcke, Anita Wiechert, Wolfgang Jaeger, Karl-Erich Pietruszka, Jörg Drepper, Thomas |
| Rapid assessment of oxygen transfer impact for Corynebacterium glutamicum Erschienen in: Bioprocess and biosystems engineering (2014) | Käß, Friedrich Prasad, Arjun Tillack, Jana Moch, Matthias Giese, Heiner Büchs, Jochen Wiechert, Wolfgang Oldiges, Marco (Corresponding author) |
| First- and Second-Order Parameter Sensitivities of a Metabolically and Isotopically Non-Stationary Biochemical Network Model Erschienen in: Proceedings - 9th International Modelica Conference : September 3 - 5, 2012, Munich, Germany / , Martin Otter ; Dirk Zimmer (2012) | Hannemann-Tamás, Ralf Tillack, Jana Schmitz, Moritz Förster, Michael Wyes, Jutta Nöh, Katharina von Lieres und Wilkau, Eric Naumann, Uwe Wiechert, Wolfgang Marquardt, Wolfgang |