Fungi 4 Future – Facilitating Fungal Fed-Batch Fermentations
- Biochemical Engineering
- Focus/Key Topic:
Do you want to make a change? Do you want to contribute to a sustainable future?
Try Fungal Biotechnology!
According to EUROFUNG, filamentous fungal systems have a huge potential to improve human welfare and to help society to address key challenges of the twenty-first century .
Filamentous fungi are often superior to bacterial and yeast based production systems due to their metabolic versatility, robustness and secretory capacity. The benefits of fungal cell factories for white and red biotechnology are demonstrated by the increasing number of established large-scale manufacturing processes for industries including food and feed, pharma, paper and pulp, detergent, textile and bio-fuel. As filamentous fungi already produce the majority of enzymes used worldwide, they are of key importance for a sustainable bio-economy .
During your project, you will work with a unique fungal strain that exhibits a well-controlled morphology and is already in use by global players of the pharmaceutical and chemical industry. Your task will be to investigate how the growth, morphology, and enzyme production in small-scale fed-batch systems - microtiter plates und shake flasks - relates to fed-batch fermentations in stirred tank reactors.
To achieve the transfer of results from shaken small-scale screening systems to stirred lab-scale production systems (and back) you will employ most or all of the following technologies:
- Non-invasive online monitoring systems
- A novel online viscosity measurement device for morphology monitoring
- Innovative fed-batch microtiter plates and shake flasks
- Automated image analysis of fungal morphology
- Automated enzyme assays
During your project, you will get…
- … a deeper understanding of biotechnological processes in various scales and the relations between those
- … an introduction into a seminal topic with the flexibility to introduce your own ideas
- … the chance to work on a topic where your results may have a direct impact on a real process
- … a dedicated supervision
For this project, you should be…
- …motivated to dig deep into a multifaceted topic at the intersection of natural and engineering sciences and discuss your ideas
- …enthusiastic to work in the lab and to get to know, understand and apply novel technologies
- …determined to show a reliable, independent and result-oriented work ethic
Your work on this project should start between March and April 2020. If you are interested, do not hesitate to contact me. Whether in English or German, I will gladly provide you with a more detailed project description at a personal meeting.
 Meyer et al. (2016), Fungal Biol Biotechnol; Current challenges of research on filamentous fungi in relation to human welfare and a sustainable bio‑economy: a white paper